| No. | Slide Name | Case Info |
|---|---|---|
| 1 | 8-year-old female, known case of ETP-ALL (post-therapy), with a clinical suspicion of relapse on maintenance phase. Recent bone marrow aspiration with flow cytometric immunophenotyping, and bone marrow biopsy - Uninvolved PET-CT: Multiple FDG-avid enlarged bilateral suboccipital, level 2 and level 5 lymph nodes, the largest measuring 1.4x1 cm, skin lesions, and multiple non-cavitating, discrete, solid nodules in both lungs, the largest measuring 2.3 cm, with a few subsegmental atelectatic bands. Cervical Lymph nodes excision biopsy performed. 1 H&E and 5 unstained slides provided. Case to Be discussed by Tata Memorial Hospital, Parel. |
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| 2 | 51-year-old female. CT scan shows an expansive lesion over right paramandibular region and involving the angle of right mandible and proximal body. Biopsy from right paramandibular region swelling. 1 H&E and 5 unstained coated slides provided. Case to be discussed by K.E.M hospital / MGM hospital. |
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| 3 | 5-year-old female, with a history of cough and cold for 2 weeks, and complaining of body ache and multiple episodes of vomiting and loss of appetite. Initial scans suggestive of hydrocephalus, leptomeningeal enhancement, and diffuse parenchymal hyperintense changes throughout the brain parenchyma. Initial histopathology report: Right frontal leptomeningeal and brain biopsy - Histomorphological features favor a possibility of organizing pachymeningitis. Microbiology testing negative for any organisms. Recent MRI brain: The ventricles appear increased in size compared to earlier scan. Enlarging bilateral subdural hygromas have decreased in size. Extensive spinal cord abnormalities are seen with T2 high-signal intensity changes within the swollen cord. Thick, T2 hypointense, arachnoidal membranes are seen coating the swollen cord throughout the spinal canal. On the post contrast T1 images, there continues to be extensive thick meningeal enhancement predominantly in the posterior fossa, with extension along cranial nerves, and within the basal cisterns and sylvian fissures. In the spinal canal, the extent seems to be thicker particularly in the dorsal region. No mass lesion identified. Clinical diagnosis: Communication hydrocephalus with pachymeningitis. Conservative management failed, so multiple re-biopsies from cranial dura, lumbar and cervical arachnoid were performed and sent for histopathology and microbiology testing. Biopsy from lumbar arachnoid given. 1 H&E and 5 unstained slides provided. Case to be discussed by S L Raheja Hospital / Somaiya Hospital / Centre of Oncopathology. |
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| 4 | 38-year-old male presented with swelling in the right proximal thigh, which had been present for approximately six months. The patient reported a superficial, non-painful, and non-progressive swelling. There is no history of preceding trauma or injury to the area. The swelling has been stable in size and character since its initial appearance six months ago. An MRI of the right thigh was performed to evaluate the etiology of the mass. The MRI study is consistent with a subcutaneous hematoma. However, an excision biopsy was performed. One H &E slide and 5 unstained slides provided. Case to be discussed by Gov. Grant Medical College and J.J Hospital / Terna Medical College. |
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| 5 | 29-year-old male complaints of breathlessness on exertion. CT thorax showed a 10 x 5cm mediastinal mass.EBUS guided FNAC done reported outside as granulomatous lymphadenitis, started on AKT, symptoms got aggravated and patient also developed skin and mucosal lesions. Excision of mass was done. Grossly the mass weighted 282 gm and measured 12 x 10 x 5cm. External surface was bosselated. Cut surface was white fleshy, vaguely lobulated with areas of necrosis and focal hemorrhage. Patient was free of symptoms on follow up. In 2025 on follow up CT thorax showed residual / recurrent mass and was excised. Slide 5 a. One H&E slide and seven unstained slides from the anterior mediastinal mass operated in 2023 are provided. Slide 5b. One H&E slide and three unstained slides from the residual/recurrent anterior mediastinal mass operated in 2025 are provided. Case to be discussed by Agilus Diagnostics limited / Kokilaben Ambani Hospital / ESIS Hospital |
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| 6 | Same As Above. | |
| 7 | A 65-year-old man with history of prostatic cancer complained of supraclavicular swelling. Clinically tuberculous lymphadenitis was suspected. On gross an enlarged lymphnode was received. Cut section was grey white, fleshy One H&E slide and seven unstained slides are provided. Case to be discussed by Hinduja Hospital / Lilavati Hospital / Nanavati Hospital |
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| 8 | A 47 yr lady presented with fever, cough and breathlessness since 10 days. X-Ray chest showed right pleural effusion and was started on AKT empirically. Cough and breathlessness were persistent. CT Chest: Large, mixed density predominantly hypodense lesion 16.5 x 15.5 x 14.5cms seen epicentered in right mid and lower chest showing internal peripheral heterogeneously enhancing irregular areas and central non-enhancing component with adjacent peripheral thickened enhancing pleura in right lower chest – likely neoplastic, Enlarged LNS. Outside biopsy: Round blue cell tumor. Thoracotomy with excision of right large thoracic mass with right middle lobectomy and segment VII excision was done in JHRC. A 20 x 16 x 7cm already cut opened distorted lobulated large soft tissue mass with adherent 5 x 4cm lung parenchyma was received. The cut surface of the mass showed grey white, friable, glistening nodules ranging in size from 3-6cm at periphery with large central area of necrosis. 2 H&E slides one each from mass, ilar lymph node and 7 unstained slides are provided. Case to be discussed by TNMC (Nair Hospital) / Rajiv Gandhi Medical College. |
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| 9 | Same As Above. | |
| 10 | 34 year old lady presented with swelling in the central part of the neck noticed. Three months ago, H/O mild dysphagia for one month USG report – TIRADS IV, FNAC reported outside – Bethesda III Thyroid hormone levels were normal. Left hemithyroidectomy performed. On gross examination: the left lobe of thyroid measured 6 x 4 x 2.5cm. External surface was smooth. The cut surface showed a solitary well circumscribed nodule measuring 3.5 x 3 x 2.2cm in the lower part of the left lobe. The central portion of nodule showed a cystic area with few polypoidal projections within. This was surrounded by tan coloured solid area, together measuring 1.6 x 1.5cm. The outer portion of the nodule appeared brownish, homogenous and glistening. Rest of the thyroid was unremarkable. 2 HE slides + 5 unstained slides provided. Case to be discussed by L.T.M. Medical college and Hospital / D Y Patil Medial college and Hospital |
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| 11 | Same As Above. | |
| 12 | Spot for Thought-80-year-old female with liver cirrhosis and a past history of breast carcinoma (s/p right mastectomy in 2011 with adjuvant radiotherapy; no documentation available) presented with recent-onset dyspnoea and a right-sided pleural effusion. HRCT Chest: Massive right-sided pleural effusion with passive collapse of underlying lung parenchyma. Focal nodular consolidation showing tiny calcific focus is seen in the apical segment of the right upper lobe. Consolidation with air bronchogram in the right middle lobe- to rule out secondary infection. Cylindrical bronchiectasis in the right upper lobe could be a sequelae of prior infection. Right-sided pleural fluid for cytology – Two H&E slides and three IHC slides digitalized. Case to be discussed by Breach Candy Hospital / Saifee Hospital / HNCII / Metropolis. |
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| 13 | Same As Above. | |
| 14 | Same As Above. | |
| 15 | Same As Above. | |
| 16 | Same As Above. |